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KMID : 0624620190520010003
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BMB Reports
2019 Volume.52 No. 1 p.3 ~ p.4
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Juxtacrine regulation of cellular senescence
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Narita Masashi
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Abstract
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Cellular senescence is defined as a state of stable cell cycle exit in response to various stimuli, which include both cytotoxic stress and physiological cues. In addition to the core non-proliferative aspect, senescence is associated with diverse functionalities, which contribute to the role of senescence in a wide range of pathological and physiological processes. Such functionality is often mediated by the capability of senescent cells to communicate with their surroundings. Emerging evidence suggests that senescence is not a single entity, but a dynamic and heterogeneous collective phenotype. Understanding the diverse nature of senescence should provide insights into the complexity of tissue homeostasis and its disruption, such as in aging and tumorigenesis.
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KEYWORD
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Epigenetics, NOTCH, SAHF, SASP, Senescence
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